SIRT2 directs the replication stress response through CDK9 deacetylation

Sirtuin 2 (SIRT2) is a sirtuin family deacetylase that directs acetylome signaling, protects genome integrity, and is a murine tumor suppressor. We show that SIRT2 directs replication stress responses by regulating the activity of cyclin-dependent kinase 9 (CDK9), a protein required for recovery fro...

Full description

Saved in:

Bibliographic Details
Main Authors:	Zhang, Hui, Park, Seong-Hoon, Pantazides, Brooke G., Karpiuk, Oleksandra, Warren, Matthew D., Hardy, Claire W., Duong, Duc M., Park, So-Jeong, Kim, Hyun-Seok, Vassilopoulos, Athanassios, Seyfried, Nicholas T., Johnsen, Steven A., Gius, David, Yu, David S.
Format:	Artigo
Language:	Inglês
Published:	National Academy of Sciences 2013
Subjects:	Biological Sciences
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3746840/ https://ncbi.nlm.nih.gov/pubmed/23898190 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1301463110
Tags:	Add Tag No Tags, Be the first to tag this record!

SIRT2 directs the replication stress response through CDK9 deacetylation

Similar Items