SIRT2 directs the replication stress response through CDK9 deacetylation

Sirtuin 2 (SIRT2) is a sirtuin family deacetylase that directs acetylome signaling, protects genome integrity, and is a murine tumor suppressor. We show that SIRT2 directs replication stress responses by regulating the activity of cyclin-dependent kinase 9 (CDK9), a protein required for recovery fro...

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Hauptverfasser: Zhang, Hui, Park, Seong-Hoon, Pantazides, Brooke G., Karpiuk, Oleksandra, Warren, Matthew D., Hardy, Claire W., Duong, Duc M., Park, So-Jeong, Kim, Hyun-Seok, Vassilopoulos, Athanassios, Seyfried, Nicholas T., Johnsen, Steven A., Gius, David, Yu, David S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2013
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3746840/
https://ncbi.nlm.nih.gov/pubmed/23898190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1301463110
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