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N-Aroyl Indole Thiobarbituric Acids as Inhibitors of DNA Repair and Replication Stress Response Polymerases
Using a robust and quantitative assay, we have identified a novel class of DNA polymerase inhibitors that exhibits some specificity against an enzyme involved in resistance to anti-cancer drugs, namely human DNA polymerase eta (hpol η). In our initial screen, we identified the indole thiobarbituric...
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| 主要な著者: | , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3746001/ https://ncbi.nlm.nih.gov/pubmed/23679919 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb400305r |
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