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High Glucose-Induced Oxidative Stress Increases the Copy Number of Mitochondrial DNA in Human Mesangial Cells

Oxidative damage to mitochondrial DNA (mtDNA) has been linked to the pathogenicity of diabetic nephropathy. We tested the hypothesis that mtDNA copy number may be increased in human mesangial cells in response to high glucose-induced reactive oxygen species (ROS) to compensate for damaged mtDNA. The...

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Detalhes bibliográficos
Main Authors: Al-Kafaji, Ghada, Golbahar, Jamal
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3745925/
https://ncbi.nlm.nih.gov/pubmed/23984405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/754946
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