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Increased mitochondrial DNA deletions and copy number in transfusion-dependent thalassemia
BACKGROUND. Iron overload is the primary cause of morbidity in transfusion-dependent thalassemia. Increase in iron causes mitochondrial dysfunction under experimental conditions, but the occurrence and significance of mitochondrial damage is not understood in patients with thalassemia. METHODS. Mito...
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| Publicado en: | JCI Insight |
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| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Clinical Investigation
2016
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5003175/ https://ncbi.nlm.nih.gov/pubmed/27583305 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.88150 |
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