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Single-molecule spectroscopy of the β(2) adrenergic receptor: Observation of conformational substates in a membrane protein

Single-molecule studies of the conformations of the intact β(2) adrenergic receptor were performed in solution. Photon bursts from the fluorescently tagged adrenergic receptor in a micelle were recorded. A photon-burst algorithm and a Poisson time filter were implemented to characterize single molec...

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Main Authors: Peleg, Gadi, Ghanouni, Pejman, Kobilka, Brian K., Zare, Richard N.
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 2001
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC37459/
https://ncbi.nlm.nih.gov/pubmed/11438704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.151239698
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