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Effects of collagen deposition on passive and active mechanical properties of large pulmonary arteries in hypoxic pulmonary hypertension

Proximal pulmonary artery (PA) stiffening is a strong predictor of mortality in pulmonary hypertension. Collagen accumulation is mainly responsible for PA stiffening in hypoxia-induced pulmonary hypertension (HPH) in mouse models. We hypothesized that collagen cross-linking and the type I isoform ar...

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Main Authors: Wang, Zhijie, Lakes, Roderic S., Eickhoff, Jens C., Chesler, Naomi C.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3745811/
https://ncbi.nlm.nih.gov/pubmed/23377784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10237-012-0467-7
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