A Novel Aldehyde Dehydrogenase-3 Activator (Alda-89) Protects Submandibular Gland Function from Irradiation without Accelerating Tumor Growth

PURPOSE: To determine the effect of Alda-89 (an ALDH3 activitor) on (1) the function of irradiated (RT) submandibular gland (SMG) in mice, (2) its toxicity profile and (3) its effect on the growth of head and neck cancer (HNC) in vitro and in vivo. EXPERIMENTAL DESIGN: Adult mice were infused with A...

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Hauptverfasser: Xiao, Nan, Cao, Hongbin, Chen, Che-Hong, Kong, Christina S., Ali, Rehan, Chan, Cato, Sirjani, Davud, Graves, Edward, Koong, Albert, Giaccia, Amato, Mochly-Rosen, Daria, Le, Quynh-Thu
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3745542/
https://ncbi.nlm.nih.gov/pubmed/23812668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-0127
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