Involvement of the GluN2A and GluN2B Subunits in Synaptic and Extrasynaptic N-methyl-d-aspartate Receptor Function and Neuronal Excitotoxicity

GluN2A and GluN2B are the major subunits of functional NMDA receptors (NMDAR). Previous studies have suggested that GluN2A and GluN2B may differentially mediate NMDAR function at synaptic and extrasynaptic locations and play opposing roles in excitotoxicity, such as neurodegeneration triggered by is...

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Detalhes bibliográficos
Main Authors: Zhou, Xianju, Ding, Qi, Chen, Zhuoyou, Yun, Huifang, Wang, Hongbing
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3745357/
https://ncbi.nlm.nih.gov/pubmed/23839940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.482000
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