Ligands Raise the Constraint That Limits Constitutive Activation in G Protein-coupled Opioid Receptors

Using a cell-free bioluminescence resonance energy transfer strategy we compared the levels of spontaneous and ligand-induced receptor-G protein coupling in δ (DOP) and μ (MOP) opioid receptors. In this assay GDP can suppress spontaneous coupling, thus allowing its quantification. The level of const...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Vezzi, Vanessa, Onaran, H. Ongun, Molinari, Paola, Guerrini, Remo, Balboni, Gianfranco, Calò, Girolamo, Costa, Tommaso
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2013
Gaiak:
Signal Transduction
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3745342/
https://ncbi.nlm.nih.gov/pubmed/23836900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.474452
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