Cell Contact-dependent Functional Selectivity of β(2)-Adrenergic Receptor Ligands in Stimulating cAMP Accumulation and Extracellular Signal-regulated Kinase Phosphorylation

Activation of β(2)-adrenegic receptor (β(2)-AR) leads to an increase in intracellular cAMP and activation of ERK. These two signals are activated by the interaction of the receptor with different transducer partners. We showed that the intrinsic activities of β(2)-AR ligands for stimulating cAMP pro...

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Detalhes bibliográficos
Main Authors: Kaya, Ali I., Onaran, H. Ongun, Özcan, Gülnihal, Ambrosio, Caterina, Costa, Tommaso, Balli, Sezen, Uğur, Özlem
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3307305/
https://ncbi.nlm.nih.gov/pubmed/22241475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.301820
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