Vasopressin receptor 2 mutations in the nephrogenic syndrome of inappropriate antidiuresis show different mechanisms of constitutive activation for G protein coupled receptors

Vasopressin receptor 2 (V2R) mutations causing the nephrogenic syndrome of inappropriate antidiuresis (NSIAD) can generate two constitutively active receptor phenotypes. One type results from residue substitutions in several V2R domains and is sensitive to vaptan inverse agonists. The other is only...

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Publicado no:Sci Rep
Main Authors: Vezzi, Vanessa, Ambrosio, Caterina, Grò, Maria Cristina, Molinari, Paola, Süral, Gökçe, Costa, Tommaso, Onaran, H. Ongun, Cotecchia, Susanna
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7272623/
https://ncbi.nlm.nih.gov/pubmed/32499611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-65996-w
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