The Structure of the Ternary Complex of Krev Interaction Trapped 1 (KRIT1) Bound to Both the Rap1 GTPase and the Heart of Glass (HEG1) Cytoplasmic Tail

Loss of function mutation in Krev interaction trapped 1 (KRIT1) causes autosomal dominant familial cerebral cavernous malformations and disrupts cardiovascular development. The biological function of KRIT1 requires that its FERM (band 4.1, ezrin, radixin, moesin) domain physically interact with both...

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Hlavní autoři: Gingras, Alexandre R., Puzon-McLaughlin, Wilma, Ginsberg, Mark H.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2013
Témata:
Protein Structure and Folding
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3745310/
https://ncbi.nlm.nih.gov/pubmed/23814056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.462911
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