X-ray crystal structures of the Escherichia coli RNA polymerase in complex with Benzoxazinorifamycins

Rifampin, a semi-synthetic rifamycin, is the cornerstone of current tuberculosis treatment. Among many semi-synthetic rifamycins, benzoxazinorifamycins have great potential for TB treatment due to their superior affinity for wild-type and rifampin-resistant Mycobacterium tuberculosis RNA polymerases...

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Autores principales: Molodtsov, Vadim, Nawarathne, Irosha N., Scharf, Nathan T., Kirchhoff, Paul D., Hollis Showalter, H. D., Garcia, George A., Murakami, Katsuhiko S.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3745299/
https://ncbi.nlm.nih.gov/pubmed/23679862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm4004889
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