The Cardioprotective Mechanism of Diazoxide Involves the Inhibition of Succinate Dehydrogenase

BACKGROUND: The adenosine triphosphate-sensitive potassium (K(ATP)) channel opener, diazoxide, preserves myocyte volume homeostasis and contractility during stress via an unknown mechanism. Pharmacologic overlap has been suggested between succinate dehydrogenase (SDH) activity and K(ATP) channel mod...

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Hauptverfasser: Anastacio, Melissa M., Kanter, Evelyn M., Makepeace, Carol, Keith, Angela D., Zhang, Haixia, Schuessler, Richard B., Nichols, Colin G., Lawton, Jennifer S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3745224/
https://ncbi.nlm.nih.gov/pubmed/23642436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.athoracsur.2013.03.035
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