Structural and functional insights into pattern recognition by the innate immune receptor RIG-I

RIG-I is a cytosolic helicase that senses 5’-ppp-RNA contained in negative strand RNA viruses and triggers innate antiviral immune responses. Calorimetric binding studies establish that the RIG-I C-terminal regulatory domain (CTD) binds to blunt-end double-stranded 5’-ppp-RNA a factor of 17 more tig...

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Autori principali: Wang, Yanli, Ludwig, Janos, Schuberth, Christine, Goldeck, Marion, Schlee, Martin, Li, Haitao, Juranek, Stefan, Sheng, Gang, Micura, Ronald, Tuschl, Thomas, Hartmann, Gunther, Patel, Dinshaw J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3744876/
https://ncbi.nlm.nih.gov/pubmed/20581823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1863
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