Low-Dose Paclitaxel Ameliorates Pulmonary Fibrosis by Suppressing TGF-β1/Smad3 Pathway via miR-140 Upregulation

Abnormal TGF-β1/Smad3 activation plays an important role in the pathogenesis of pulmonary fibrosis, which can be prevented by paclitaxel (PTX). This study aimed to investigate an antifibrotic effect of the low-dose PTX (10 to 50 nM in vitro, and 0.6 mg/kg in vivo). PTX treatment resulted in phenotyp...

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Detalhes bibliográficos
Main Authors: Wang, Congjie, Song, Xiaodong, Li, Youjie, Han, Fang, Gao, Shuyan, Wang, Xiaozhi, Xie, Shuyang, Lv, Changjun
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3744547/
https://ncbi.nlm.nih.gov/pubmed/23967091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0070725
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