CTA095, a Novel Etk and Src Dual Inhibitor, Induces Apoptosis in Prostate Cancer Cells and Overcomes Resistance to Src Inhibitors

Etk is a non-receptor tyrosine kinase, which provides a strong survival signal in human prostate cancer cells. Src, another tyrosine kinase that cross-activates with Etk, has been shown to play an important role in prostate cancer metastasis. Herein, we discovered a new class of Etk inhibitors. With...

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Bibliographic Details
Main Authors: Guo, Wenchang, Liu, Ruiwu, Bhardwaj, Gaurav, Ma, Ai-Hong, Changou, Chun, Yang, Joy C., Li, Yuanpei, Feng, Caihong, Luo, Yan, Mazloom, Anisha, Sanchez, Eduardo, Wang, Yan, Huang, Wenzhe, Patterson, Randen, Evans, Christopher P., Lam, Kit S., Kung, Hsing-Jien
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3744530/
https://ncbi.nlm.nih.gov/pubmed/23967135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0070910
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