Molecular Characteristics of CTA056, a Novel Interleukin-2-Inducible T-Cell Kinase Inhibitor that Selectively Targets Malignant T Cells and Modulates Oncomirs

Interleukin-2-inducible T-cell kinase (Itk) is a member of the Btk (Bruton's tyrosine kinase) family of tyrosine kinases. Itk plays an important role in normal T-cell functions and in the pathophysiology of both autoimmune diseases and T-cell malignancies. Here, we describe the initial characte...

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Main Authors: Guo, Wenchang, Liu, Ruiwu, Ono, Yoko, Ma, Ai-Hong, Martinez, Anthony, Sanchez, Eduardo, Wang, Yan, Huang, Wenzhe, Mazloom, Anisha, Li, Jixian, Ning, Jinying, Maverakis, Emanual, Lam, Kit S., Kung, Hsing-Jien
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3477223/
https://ncbi.nlm.nih.gov/pubmed/22899868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.112.079889
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