ATP bound to the origin recognition complex is important for preRC formation

The origin recognition complex (ORC) binds origins of replication and directs the assembly of a higher order protein complex at these sites. ORC binds and hydrolyzes ATP in vitro. ATP binding to the largest subunit of ORC, Orc1p, stimulates specific binding to origin DNA; however, the function of AT...

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Bibliographic Details
Main Authors: Klemm, Richard D., Bell, Stephen P.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2001
Subjects:
Colloquium Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC37444/
https://ncbi.nlm.nih.gov/pubmed/11459976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.131006898
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