Bortezomib in the rapid reduction of high sustained antibody titers in disorders treated with therapeutic protein: lessons learned from Pompe disease

PURPOSE: High sustained antibody titers complicate many disorders treated with a therapeutic protein, including those treated with enzyme replacement therapy, such as Pompe disease. Although enzyme replacement therapy with alglucosidase alfa (Myozyme) in Pompe disease has improved the prognosis of t...

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Detalhes bibliográficos
Main Authors: Banugaria, Suhrad G., Prater, Sean N., McGann, Judeth K., Feldman, Jonathan D., Tannenbaum, Jesse A., Bailey, Carrie, Gera, Renuka, Conway, Robert L., Viskochil, David, Kobori, Joyce A., Rosenberg, Amy S., Kishnani, Priya S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3744338/
https://ncbi.nlm.nih.gov/pubmed/23060045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gim.2012.110
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