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Early phase trial design for assessing several dose levels for toxicity and efficacy for targeted agents

BACKGROUND: Traditional phase I trials are designed to be conservative. Many times a traditional phase I trial design stops at a dose level below the maximal tolerated dose (MTD), thus potentially treating patients at a suboptimal level in all subsequent trials. This has been confirmed by our recent...

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Hlavní autoři: Hoering, Antje, Mitchell, Alan, LeBlanc, Michael, Crowley, John
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3744092/
https://ncbi.nlm.nih.gov/pubmed/23529697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1740774513480961
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