Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration

Transcription factor Nrf2 and its repressor Keap1 regulate a network of cytoprotective genes involving more than 1% of the genome, their best known targets being drug-metabolizing and antioxidant genes. Here we demonstrate a novel role for this pathway in directly regulating mitochondrial bioenerget...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Holmström, Kira M., Baird, Liam, Zhang, Ying, Hargreaves, Iain, Chalasani, Annapurna, Land, John M., Stanyer, Lee, Yamamoto, Masayuki, Dinkova-Kostova, Albena T., Abramov, Andrey Y.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The Company of Biologists 2013
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3744067/
https://ncbi.nlm.nih.gov/pubmed/23951401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.20134853
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