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Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex

The transcription factor NF-E2 p45-related factor 2 (Nrf2), a master regulator of cytoprotective genes, is controlled by dimeric Kelch-like ECH associated protein 1 (Keap1), a substrate adaptor protein for Cullin3/RING-box protein 1 ubiquitin ligase, which normally targets Nrf2 for ubiquitination an...

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Detalhes bibliográficos
Main Authors: Baird, Liam, Llères, David, Swift, Sam, Dinkova-Kostova, Albena T.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3780858/
https://ncbi.nlm.nih.gov/pubmed/23986495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1305687110
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