DICER- and AGO3-dependent Generation of Retinoic Acid-Induced DR2 Alu RNAs (riRNAs) Regulates Human Stem Cell Proliferation

While liganded nuclear receptors are established to regulate Pol II-dependent transcription units, their role in regulating Pol III-transcribed DNA repeats remains largely unknown. Here, we report that ~2–3% of the ~100,000–200,000 human DR2 Alu repeats in proximity to activated Pol II transcription...

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Autori principali: Hu, QiDong, Tanasa, Bogdan, Trabucchi, Michele, Li, Wenbo, Zhang, Jie, Ohgi, Kenneth A., Rose, David W., Glass, Christopher K., Rosenfeld, Michael G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3743530/
https://ncbi.nlm.nih.gov/pubmed/23064648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2400
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