Oxygen-coupled Redox Regulation of the Skeletal Muscle Ryanodine Receptor/Ca(2+) Release Channel (RyR1): SITES AND NATURE OF OXIDATIVE MODIFICATION

In mammalian skeletal muscle, Ca(2+) release from the sarcoplasmic reticulum (SR) through the ryanodine receptor/Ca(2+)-release channel RyR1 can be enhanced by S-oxidation or S-nitrosylation of separate Cys residues, which are allosterically linked. S-Oxidation of RyR1 is coupled to muscle oxygen te...

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Bibliographic Details
Main Authors: Sun, Qi-An, Wang, Benlian, Miyagi, Masaru, Hess, Douglas T., Stamler, Jonathan S.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3743473/
https://ncbi.nlm.nih.gov/pubmed/23798702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.480228
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