A Mathematical Model of Tryptophan Metabolism via the Kynurenine Pathway Provides Insights into the Effects of Vitamin B-6 Deficiency, Tryptophan Loading, and Induction of Tryptophan 2,3-Dioxygenase on Tryptophan Metabolites(1)(2)(3)

Vitamin B-6 deficiency is associated with impaired tryptophan metabolism because of the coenzyme role of pyridoxal 5′-phosphate (PLP) for kynureninase and kynurenine aminotransferase. To investigate the underlying mechanism, we developed a mathematical model of tryptophan metabolism via the kynureni...

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Detalhes bibliográficos
Main Authors: Rios-Avila, Luisa, Nijhout, H. Frederik, Reed, Michael C., Sitren, Harry S., Gregory, Jesse F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Nutrition 2013
Assuntos:
Methodology and Mathematical Modeling
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3743279/
https://ncbi.nlm.nih.gov/pubmed/23902960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3945/jn.113.174599
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