Expression of Tryptophan 2,3-Dioxygenase and Production of Kynurenine Pathway Metabolites in Triple Transgenic Mice and Human Alzheimer's Disease Brain

To assess the role of the kynurenine pathway in the pathology of Alzheimer's disease (AD), the expression and localization of key components of the kynurenine pathway including the key regulatory enzyme tryptophan 2,3 dioxygenase (TDO), and the metabolites tryptophan, kynurenine, kynurenic acid...

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Detalhes bibliográficos
Main Authors: Wu, Wei, Nicolazzo, Joseph A., Wen, Li, Chung, Roger, Stankovic, Roger, Bao, Shisan S., Lim, Chai K., Brew, Bruce J., Cullen, Karen M., Guillemin, Gilles J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3632609/
https://ncbi.nlm.nih.gov/pubmed/23630570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0059749
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