Repression of the Human Papillomavirus E6 Gene Initiates p53-Dependent, Telomerase-Independent Senescence and Apoptosis in HeLa Cervical Carcinoma Cells

Cervical cancer cells express high-risk human papillomavirus (HPV) E6 and E7 proteins. When both HPV oncogenes are repressed in HeLa cervical carcinoma cells, the dormant p53 and retinoblastoma (Rb) tumor suppressor pathways are activated, and the cells undergo senescence in the absence of apoptosis...

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Publikašuvnnas:	J Virol
Váldodahkkit:	Horner, Stacy M., DeFilippis, Rosa Anna, Manuelidis, Laertes, DiMaio, Daniel
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	American Society for Microbiology (ASM) 2004
Fáttát:	Transformation and Oncogenesis
Liŋkkat:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC374296/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15047823/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.78.8.4063-4073.2004
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