Repression of the Human Papillomavirus E6 Gene Initiates p53-Dependent, Telomerase-Independent Senescence and Apoptosis in HeLa Cervical Carcinoma Cells

Cervical cancer cells express high-risk human papillomavirus (HPV) E6 and E7 proteins. When both HPV oncogenes are repressed in HeLa cervical carcinoma cells, the dormant p53 and retinoblastoma (Rb) tumor suppressor pathways are activated, and the cells undergo senescence in the absence of apoptosis...

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Bibliographische Detailangaben
Hauptverfasser: Horner, Stacy M., DeFilippis, Rosa Anna, Manuelidis, Laertes, DiMaio, Daniel
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2004
Schlagworte:
Transformation and Oncogenesis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC374296/
https://ncbi.nlm.nih.gov/pubmed/15047823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.8.4063-4073.2004
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