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Repression of the Human Papillomavirus E6 Gene Initiates p53-Dependent, Telomerase-Independent Senescence and Apoptosis in HeLa Cervical Carcinoma Cells

Cervical cancer cells express high-risk human papillomavirus (HPV) E6 and E7 proteins. When both HPV oncogenes are repressed in HeLa cervical carcinoma cells, the dormant p53 and retinoblastoma (Rb) tumor suppressor pathways are activated, and the cells undergo senescence in the absence of apoptosis...

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Bibliografski detalji
Glavni autori: Horner, Stacy M., DeFilippis, Rosa Anna, Manuelidis, Laertes, DiMaio, Daniel
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2004
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC374296/
https://ncbi.nlm.nih.gov/pubmed/15047823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.8.4063-4073.2004
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