Repression of the Human Papillomavirus E6 Gene Initiates p53-Dependent, Telomerase-Independent Senescence and Apoptosis in HeLa Cervical Carcinoma Cells

Cervical cancer cells express high-risk human papillomavirus (HPV) E6 and E7 proteins. When both HPV oncogenes are repressed in HeLa cervical carcinoma cells, the dormant p53 and retinoblastoma (Rb) tumor suppressor pathways are activated, and the cells undergo senescence in the absence of apoptosis...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Horner, Stacy M., DeFilippis, Rosa Anna, Manuelidis, Laertes, DiMaio, Daniel
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2004
Témata:
Transformation and Oncogenesis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC374296/
https://ncbi.nlm.nih.gov/pubmed/15047823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.8.4063-4073.2004
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky