Bovine Herpesvirus Tegument Protein VP22 Enhances Thymidine Kinase/Ganciclovir Suicide Gene Therapy for Neuroblastomas Compared to Herpes Simplex Virus VP22

Herpesvirus tegument protein VP22 can enhance the effect of therapeutic proteins in gene therapy, such as thymidine kinase (tk) and p53; however, the mechanism is unclear or controversial. In this study, mammalian expression vectors carrying bovine herpesvirus 1 (BHV-1) VP22 (BVP22) or herpes simple...

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Autors principals: Qiu, Zhaohua, Harms, Jerome S., Zhu, Jun, Splitter, Gary A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2004
Matèries:
Gene Therapy
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC374295/
https://ncbi.nlm.nih.gov/pubmed/15047837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.8.4224-4233.2004
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