Defective RNA Replication and Late Gene Expression in Temperature-Sensitive Influenza Viruses Expressing Deleted Forms of the NS1 Protein

Influenza A virus mutants expressing C-terminally deleted forms of the NS1 protein (NS1-81 and NS1-110) were generated by plasmid rescue. These viruses were temperature sensitive and showed a small plaque size at the permissive temperature. The accumulation of virion RNA in mutant virus-infected cel...

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Detalhes bibliográficos
Main Authors: Falcón, Ana M., Marión, Rosa M., Zürcher, Thomas, Gómez, Paulino, Portela, Agustín, Nieto, Amelia, Ortín, Juan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC374278/
https://ncbi.nlm.nih.gov/pubmed/15047804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.8.3880-3888.2004
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