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5-Lipoxygenase Activating Protein Reduction Ameliorates Cognitive Deficit, Synaptic Dysfunction, and Neuropathology in a Mouse Model of Alzheimer’s Disease

BACKGROUND: 5-lipoxygenase activating protein (FLAP) is abundantly present in the central nervous system. Although its function has been extensively interrogated in the context of peripheral inflammation, novel roles for this protein are emerging in the central nervous system. The objective of our s...

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Main Authors: Giannopoulos, Phillip F., Chu, Jin, Joshi, Yash B., Sperow, Margaret, Li, Jin-Guo, Kirby, Lynn G., Praticò, Domenico
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3742720/
https://ncbi.nlm.nih.gov/pubmed/23683389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2013.04.009
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