Reactive oxygen species mediate Cr(VI)-induced carcinogenesis through PI3K/AKT-dependent activation of GSK-3 β/β-catenin signaling

Cr(VI) compounds are known human carcinogens that primarily target the lungs. Cr(VI) produces reactive oxygen species (ROS), but the exact effects of ROS on the signaling molecules involved in Cr(VI)-induced carcinogenesis have not been extensively studied. Chronic exposure of human bronchial epithe...

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Autors principals: Son, Young-Ok, Pratheeshkumar, Poyil, Lei, Wang, Wang, Xin, Kim, Dong-Hern, Lee, Ju-Yeon, Zhang, Zhuo, Lee, Jeong-Chae, Shi, Xianglin
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3742697/
https://ncbi.nlm.nih.gov/pubmed/23707771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2013.04.036
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