Targeting 6-Phosphofructo-2-Kinase (PFKFB3) as a Therapeutic Strategy against Cancer

In human cancers, loss of PTEN, stabilization of HIF-1α and activation of Ras and AKT converge to increase the activity of a key regulator of glycolysis, 6-phosphofructo-2-kinase(PFKFB3). This enzyme synthesizes fructose 2,6-bisphosphate (F26BP) which is an activator of 6-phosphofructo-1-kinase, a k...

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Главные авторы: Clem, Brian F., O’Neal, Julie, Tapolsky, Gilles, Clem, Amy L., Imbert-Fernandez, Yoannis, Kerr, Daniel A., Klarer, Alden C., Redman, Rebecca, Miller, Donald M., Trent, John O., Telang, Sucheta, Chesney, Jason
Формат: Artigo
Язык:Inglês
Опубликовано: 2013
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3742633/
https://ncbi.nlm.nih.gov/pubmed/23674815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-13-0097
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