The Differential Sensitivity of Human and Rhesus Macaque CCR5 to Small-Molecule Inhibitors of Human Immunodeficiency Virus Type 1 Entry Is Explained by a Single Amino Acid Difference and Suggests a Mechanism of Action for These Inhibitors

AD101 and SCH-C are two chemically related small molecules that inhibit the entry of human immunodeficiency virus type 1 (HIV-1) via human CCR5. AD101 also inhibits HIV-1 entry via rhesus macaque CCR5, but SCH-C does not. Among the eight residues that differ between the human and macaque versions of...

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Detalhes bibliográficos
Main Authors: Billick, Erika, Seibert, Christoph, Pugach, Pavel, Ketas, Tom, Trkola, Alexandra, Endres, Michael J., Murgolo, Nicholas J., Coates, Elizabeth, Reyes, Gregory R., Baroudy, Bahige M., Sakmar, Thomas P., Moore, John P., Kuhmann, Shawn E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC374253/
https://ncbi.nlm.nih.gov/pubmed/15047829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.8.4134-4144.2004
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