Analysis of the Mechanism by Which the Small-Molecule CCR5 Antagonists SCH-351125 and SCH-350581 Inhibit Human Immunodeficiency Virus Type 1 Entry

Human immunodeficiency virus type 1 (HIV-1) entry is mediated by the consecutive interaction of the envelope glycoprotein gp120 with CD4 and a coreceptor such as CCR5 or CXCR4. The CCR5 coreceptor is used by the most commonly transmitted HIV-1 strains that often persist throughout the course of infe...

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Dettagli Bibliografici
Autori principali: Tsamis, Fotini, Gavrilov, Svetlana, Kajumo, Francis, Seibert, Christoph, Kuhmann, Shawn, Ketas, Tom, Trkola, Alexandra, Palani, Anadan, Clader, John W., Tagat, Jayaram R., McCombie, Stuart, Baroudy, Bahige, Moore, John P., Sakmar, Thomas P., Dragic, Tatjana
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2003
Soggetti:
Vaccines and Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC153966/
https://ncbi.nlm.nih.gov/pubmed/12692222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.9.5201-5208.2003
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