Analysis of the Mechanism by Which the Small-Molecule CCR5 Antagonists SCH-351125 and SCH-350581 Inhibit Human Immunodeficiency Virus Type 1 Entry

Human immunodeficiency virus type 1 (HIV-1) entry is mediated by the consecutive interaction of the envelope glycoprotein gp120 with CD4 and a coreceptor such as CCR5 or CXCR4. The CCR5 coreceptor is used by the most commonly transmitted HIV-1 strains that often persist throughout the course of infe...

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Publicado en:	J Virol
Autores principales:	Tsamis, Fotini, Gavrilov, Svetlana, Kajumo, Francis, Seibert, Christoph, Kuhmann, Shawn, Ketas, Tom, Trkola, Alexandra, Palani, Anadan, Clader, John W., Tagat, Jayaram R., McCombie, Stuart, Baroudy, Bahige, Moore, John P., Sakmar, Thomas P., Dragic, Tatjana
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 2003
Materias:	Vaccines and Antiviral Agents
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC153966/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12692222/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.77.9.5201-5208.2003
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