Paxillin mutations affect focal adhesions and lead to altered mitochondrial dynamics: Relevance to lung cancer

Cytoskeletal and focal adhesion abnormalities are observed in several types of cancer, including lung cancer. We have previously reported that paxillin (PXN) was mutated, amplified, and overexpressed in a significant number of lung cancer patient samples, that PXN protein was upregulated in more adv...

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Main Authors: Kawada, Ichiro, Hasina, Rifat, Lennon, Frances E, Bindokas, Vytautas P, Usatyuk, Peter, Tan, Yi-Hung C, Krishnaswamy, Soundararajan, Arif, Qudsia, Carey, George, Hseu, Robyn D, Robinson, Matthew, Tretiakova, Maria, Brand, Toni M, Iida, Mari, Ferguson, Mark K, Wheeler, Deric L, Husain, Aliya N, Natarajan, Viswanathan, Vokes, Everett E, Singleton, Patrick A, Salgia, Ravi
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2013
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3742497/
https://ncbi.nlm.nih.gov/pubmed/23792636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.25091
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