Synthesis and evaluation of a bifunctional chelate for development of Bi(III)-labeled radioimmunoconjugates

A new bifunctional ligand C-DEPA was designed and synthesized as a component for antibody-targeted radiation therapy (radioimmunotherapy, RIT) of cancer. C-DEPA was conjugated to a tumor targeting antibody, trastuzumab, and the corresponding C-DEPA-trastuzumab conjugate was evaluated for radiolabeli...

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Bibliographische Detailangaben
Hauptverfasser: Dadwal, Mamta, Kang, Chi Soo, Song, Hyun A, Sun, Xiang, Dai, Anzhi, Baidoo, Kwamena E., Brechbiel, Martin W., Chong, Hyun-Soon
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3741339/
https://ncbi.nlm.nih.gov/pubmed/22047687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.06.107
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