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Synthesis and evaluation of a bifunctional chelate for development of Bi(III)-labeled radioimmunoconjugates
A new bifunctional ligand C-DEPA was designed and synthesized as a component for antibody-targeted radiation therapy (radioimmunotherapy, RIT) of cancer. C-DEPA was conjugated to a tumor targeting antibody, trastuzumab, and the corresponding C-DEPA-trastuzumab conjugate was evaluated for radiolabeli...
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| Auteurs principaux: | , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3741339/ https://ncbi.nlm.nih.gov/pubmed/22047687 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.06.107 |
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