Structures of Streptococcus pneumoniae PiaA and Its Complex with Ferrichrome Reveal Insights into the Substrate Binding and Release of High Affinity Iron Transporters

Iron scarcity is one of the nutrition limitations that the Gram-positive infectious pathogens Streptococcus pneumoniae encounter in the human host. To guarantee sufficient iron supply, the ATP binding cassette (ABC) transporter Pia is employed to uptake iron chelated by hydroxamate siderophore, via...

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Bibliographic Details
Main Authors: Cheng, Wang, Li, Qiong, Jiang, Yong-Liang, Zhou, Cong-Zhao, Chen, Yuxing
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3741162/
https://ncbi.nlm.nih.gov/pubmed/23951167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0071451
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