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Menin: a scaffold protein that controls gene expression and cell signaling

The protein menin is encoded by the MEN1 gene, which is mutated in patients with multiple endocrine neoplasia type 1 (MEN1) syndrome. Although menin acts as a tumor suppressor in endocrine organs, it is required for leukemic transformation in mouse models. Menin possesses these dichotomous functions...

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Bibliografische gegevens
Hoofdauteurs: Matkar, Smita, Thiel, Austin, Hua, Xianxin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2013
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3741089/
https://ncbi.nlm.nih.gov/pubmed/23850066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tibs.2013.05.005
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