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Impaired complex IV activity in response to loss of LRPPRC function can be compensated by mitochondrial hyperfusion

Mitochondrial morphology changes in response to various stimuli but the significance of this is unclear. In a screen for mutants with abnormal mitochondrial morphology, we identified MMA-1, the Caenorhabditis elegans homolog of the French Canadian Leigh Syndrome protein LRPPRC (leucine-rich pentatri...

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Detalhes bibliográficos
Main Authors: Rolland, Stéphane G., Motori, Elisa, Memar, Nadin, Hench, Jürgen, Frank, Stephan, Winklhofer, Konstanze F., Conradt, Barbara
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3740885/
https://ncbi.nlm.nih.gov/pubmed/23878239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1303872110
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