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BACE1 regulates hippocampal astrogenesis via the Jagged1-Notch pathway
BACE1 is the sole secretase for generating β–amyloid (Aβ) in vivo and is being actively pursued as a drug target for the treatment of Alzheimer’s disease. Transmembrane BACE1 exerts its biological activity by cleaving its membrane-bound cellular substrates. Here we reveal that BACE1 directly regulat...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2013
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3740554/ https://ncbi.nlm.nih.gov/pubmed/23831026 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.06.005 |
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