Free Fatty Acids Induce Lhb mRNA but Suppress Fshb mRNA in Pituitary LβT2 Gonadotropes and Diet-Induced Obesity Reduces FSH Levels in Male Mice and Disrupts the Proestrous LH/FSH Surge in Female Mice

Female obesity is associated with insulin resistance, hyperandrogenemia, and reproductive dysfunction. We hypothesized that elevated free fatty acids (FFAs) might directly modulate pituitary gonadotropin production. FFAs caused a time- and dose-dependent increase in phosphorylation of the MAPKs p38M...

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Bibliographic Details
Main Authors: Sharma, Shweta, Morinaga, Hidetaka, Hwang, Vicky, Fan, WuQiang, Fernandez, Marina O., Varki, Nissi, Olefsky, Jerrold M., Webster, Nicholas J. G.
Format: Artigo
Language:Inglês
Published: Endocrine Society 2013
Subjects:
Reproduction-Development
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3740488/
https://ncbi.nlm.nih.gov/pubmed/23525221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2012-2218
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