The Pak4 protein kinase is required for oncogenic transformation of MDA-MB-231 breast cancer cells

The Pak4 protein kinase, normally expressed at low level in the mammary gland, is commonly overexpressed in breast cancer. Overexpression of Pak4 transforms mouse mammary epithelial cells in vitro and renders these cells tumorigenic in athymic mice in vivo. Here we show that Pak4 is also required fo...

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Bibliographic Details
Main Authors: Wong, L E, Chen, N, Karantza, V, Minden, A
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2013
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3740299/
https://ncbi.nlm.nih.gov/pubmed/23732710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oncsis.2013.13
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