Functional differences between Streptococcus pyogenes cluster 1 and cluster 2b streptokinases are determined by their β-domains

Cluster 1 streptokinases (SK1) from Streptococcus pyogenes (GAS) show substantially higher human plasminogen (hPg) activation activities and tighter hPg binding affinities than cluster 2b streptokinases (SK2b) in solution. The extent to which the different domains of SK are responsible for these dif...

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Detalhes bibliográficos
Main Authors: Zhang, Yueling, Liang, Zhong, Glinton, Kristofor, Ploplis, Victoria A., Castellino, Francis J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3740169/
https://ncbi.nlm.nih.gov/pubmed/23474243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2013.02.033
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