Synthesis, pH-Dependent, and Plasma Stability of Meropenem Prodrugs for Potential Use Against Drug-Resistant Tuberculosis

Meropenem, a broad-spectrum parenteral β-lactam antibiotic, in combination with clavulanate has recently shown efficacy in patients with extensively drug-resistant tuberculosis. As a result of meropenem’s short half-life and lack of oral bioavailability, the development of an oral therapy is warrant...

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Bibliographic Details
Main Authors: Teitelbaum, Aaron M., Meissner, Anja, Harding, Ryan A., Wong, Christopher A., Aldrich, Courtney C., Remmel, Rory P.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3740032/
https://ncbi.nlm.nih.gov/pubmed/23845282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.05.024
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