Enhanced cytotoxicity of an anti-transferrin receptor IgG3-avidin fusion protein in combination with gambogic acid against human malignant hematopoietic cells: functional relevance of iron, the receptor, and reactive oxygen species

The human transferrin receptor (hTfR) is a target for cancer immunotherapy due to its overexpression on the surface of cancer cells. We previously developed an antibody-avidin fusion protein that targets hTfR (anti-hTfR IgG3-Av) and exhibits intrinsic cytotoxicity against certain malignant cells. Ga...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Ortiz-Sánchez, E, Daniels, TR, Helguera, G, Martinez-Maza, O, Bonavida, B, Penichet, ML
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2008
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3739978/
https://ncbi.nlm.nih.gov/pubmed/18946492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2008.270
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk